RAF Typhoon jets have operated alongside France's air force in a combined operation against an subterranean weapons facility in Syrian territory operated by the IS group, as stated by the UK's MoD.
The location, identified by intelligence, was believed to be housing weapons and explosive materials, the announcement noted, and was situated in mountainous terrain just to the north of the historic site of Palmyra in the heart of Syria.
"Our aircraft used Paveway IV guided bombs to strike a number of entry passages providing entry to the facility... initial indications indicate the strike was effective," officials stated.
There was no sign of any civilian casualties in the attack conducted Saturday night and all the aircraft made a safe return, the ministry further stated.
The British jets were supported by a Voyager tanker plane.
The Islamic State group - referred to as the so-called Islamic State - established extremist governance over parts of both Syria and Iraq before its territorial defeat in 2019.
"This operation shows British leadership, and determination to stand shoulder to shoulder with our partners, to eradicate any re-emergence of Daesh and their violent and radical beliefs in the region," UK Defence Secretary the minister stated.
UK warplanes have performed patrols over Syrian airspace to "prevent any attempted comeback" of IS following its military defeat at the Baghuz confrontation in 2019, the ministry said.
"I extend gratitude to every member of the UK armed forces who took part in this operation for their expertise and their courage," he commented. "They were part of numerous UK service members on duty over Christmas and New Year. This mission, to remove terrorist threats who threaten our safety, highlights how UK forces are always on standby, continuously, ensuring Britain's security domestically and influential overseas."
In December, the United States armed forces executed what it described as a "major assault" on Daesh sites in the country, after an attack killed two American soldiers and a local interpreter in Palmyra.
The United Nations estimates Daesh still maintains between 5,000 and 7,000 militants in Iraq and Syria.